慢性疲劳综合征与运动及免疫功能研究进展(2)
作者：佚名； 更新时间：2014-12-13
锻炼会造成慢性疲劳综合征患者的免疫功能紊乱。Nijs〔36〕等对习惯静坐和经常运动的慢性疲劳综合征患者进行比较，发现经常运动会加重慢性疲劳综合征患者的症状，因而得出，经常锻炼并没有改善免疫功能，且很可能还成为细胞免疫功能紊乱的病因。
〔5〕 Evengard B,Jacks A,Pedersen NL,et al.The epidemiology of chronic fatigue in the Swedish twin registry［J］.Psychol Med,2005,35(9):1317-1326.
〔6〕 Ranjith G.Epidemiology of chronic fatigue syndrome［J］.Occup Med,2005,55(1):13-19.
〔7〕 Borish L,Schmaling K,DiClementi JD,et al.Chronic fatigue syndrome:identification of distinct subgroups on the basis of allergy and psychologic variables［J］.J Allergy Clin Immunol，1998，102(2):222-230.
〔8〕 Caligiuri M,Murray C,Buchwald D,et al.Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome［J］.J Immunol，1987，139(10):3306-3313.
〔9〕 Hilgers A,Frank J.Chronic fatigue syndrome:immune dysfunction,role of pathogens and toxic agents and neurological and cardial changes［J］.Wien Med Wochenschr，1994，144(16):399-406.
〔10〕 Kerr JR,Tyrrell DA.Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome［J］.Curr Pain Headache Rep，2003 ，7(5):333-341.
〔11〕 Amel Kashipaz MR,Swinden D,Todd I,et al.Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells［J］.Clin Exp Immunol，2003，132(2):360-365.
〔12〕 Skowera A,Cleare A,Blair D.High levels of type 2 cytokine-producing cells in chronic fatigue syndrome［J］.Clin Exp Immunol，2004，135(2):294-302.
〔13〕 Staines DR.Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders ［J］.Med Hypotheses,2005,64(3):539-542.
〔14〕 Famularo G,De Simone C,Trinchieri V,et al.Carnitines and its congeners:a metabolic pathway to the regulation of immune response and inflammation［J］.Ann N Y Acad Sci,2004,1033:132-138.
〔15〕 Takahashi T,Yu F,Zhu SJ,et al.Beneficial effect of brewers yeast extract on daily activity in a murine model of chronic fatigue syndrome［J］.Evid Based Complement Alternat Med，2006，3(1):109-115.
〔16〕 Karacabey K.Effect of regular exercise on health and disease［J］.Neuro Endocrinol Lett,2005,26(5):617-623.
〔17〕 Shephard RJ,Shek PN.Autoimmune disorders,physical activity,and training,with particular reference to rheumatoid arthritis［J］.Exerc Immunol Rev,1997，3:53-67.
〔18〕 Hutnick NA,Williams NI,Kraemer WJ,et al.Exercise and lymphocyte activation following chemotherapy for breast cancer［J］.Med Sci Sports Exerc,2005,37(11):1827-1835.
〔19〕 Timmons BW.Paediatric exercise immunology:health and clinical applications［J］.Exerc Immunol Rev,2005,11:108-144.
〔20〕 Boudreau J,Quadrilatero J,Hoffman-Goetz L,et al.Voluntary training in mice and submandibular lymphocyte response to acute exercise［J］.Med Sci Sports Exerc,2005,37(12):2038-2045.
〔21〕 Clapp LL,Richardson MT,Smith JF,et al.Acute effects of thirty minutes of light-intensity,intermittent exercise on patients with chronic fatigue syndrome［J］.Phys Ther,1999,79(8):749-756.
〔22〕 Coutts R,Weatherby R,Davie A,et al.The use of a symptom “self-report” inventory to evaluate the acceptability and efficacy of a walking program for patients suffering with chronic fatigue syndrome［J］.J Psychosom Res,2001,51(2):425-429.
〔23〕 Karen E Wallman,Alan R Morton,Carmel Goodman,et al.Exercise prescription for individuals with chronic fatigue syndrome［J］.MJA,2005,183(3):142-143.
〔24〕 Pauline Powell,Richard P.Patient education to encourage graded exercise in chronic fatigue syndrome 2-year follow-up of randomised controlled trial［J］.Br J Psychiatry,2004,184:142-146.
〔25〕 Powell P,Bentall RP,Nye FJ,et al.Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome［J］.BMJ,2001,322(7283):387-390.
〔26〕 Samoilovych VA,Hutarieva NV,Tondii LD,et al.Effect of physical factors on bioelectric properties of cell nuclei of buccal epithelium in students with chronic fatigue syndrome［J］.Lik Sprava,2005,(5-6):60-64.
〔27〕 Saidi G,Haines L.The management of children with chronic fatigue syndrome-like illness in primary care:a cross-sectional study［J］.Br J Gen Pract,2006,56(522):43-47.
〔28〕 Vilikus Z,Mareckova H,Janatkova I,et al.Risk factors for ischemic heart disease in patients with chronic fatigue syndrome［J］.Sb Lek,1998,99(1):53-61.
〔29〕 McCully KK,Malucelli E,Iotti S,et al.Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients［J］.Dyn Med,2006,5:1.
〔30〕 Nijs J,Van de Putte K,Louckx F,et al.Employment status in chronic fatigue syndrome.A cross-sectional study examining the value of exercise testing and self-reported measures for the assessment of employment status［J］.Clin Rehabil,2005,19(8):895-899.
〔31〕 Iasiukiavichene L,Vasiliauskas D.Chronic fatigue syndrome in cardiology n
4 结语
总之，慢性疲劳综合征的病因不明，且对治疗慢性疲劳综合征还没有行之有效的方法。虽然适宜的步行等运动有可能缓解慢性疲劳综合征患者的症状，改善机体免疫功能异常的状态，但运动对治疗慢性疲劳综合征的效果并没有达成共识。不过，可以试用有氧运动疗法，辅助治疗慢性疲劳综合征，达到促进健康的目的。
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〔5〕 Evengard B,Jacks A,Pedersen NL,et al.The epidemiology of chronic fatigue in the Swedish twin registry［J］.Psychol Med,2005,35(9):1317-1326.
〔6〕 Ranjith G.Epidemiology of chronic fatigue syndrome［J］.Occup Med,2005,55(1):13-19.
〔7〕 Borish L,Schmaling K,DiClementi JD,et al.Chronic fatigue syndrome:identification of distinct subgroups on the basis of allergy and psychologic variables［J］.J Allergy Clin Immunol，1998，102(2):222-230.
〔8〕 Caligiuri M,Murray C,Buchwald D,et al.Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome［J］.J Immunol，1987，139(10):3306-3313.
〔9〕 Hilgers A,Frank J.Chronic fatigue syndrome:immune dysfunction,role of pathogens and toxic agents and neurological and cardial changes［J］.Wien Med Wochenschr，1994，144(16):399-406.
〔10〕 Kerr JR,Tyrrell DA.Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome［J］.Curr Pain Headache Rep，2003 ，7(5):333-341.
〔11〕 Amel Kashipaz MR,Swinden D,Todd I,et al.Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells［J］.Clin Exp Immunol，2003，132(2):360-365.
〔12〕 Skowera A,Cleare A,Blair D.High levels of type 2 cytokine-producing cells in chronic fatigue syndrome［J］.Clin Exp Immunol，2004，135(2):294-302.
〔13〕 Staines DR.Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders ［J］.Med Hypotheses,2005,64(3):539-542.
〔14〕 Famularo G,De Simone C,Trinchieri V,et al.Carnitines and its congeners:a metabolic pathway to the regulation of immune response and inflammation［J］.Ann N Y Acad Sci,2004,1033:132-138.
〔15〕 Takahashi T,Yu F,Zhu SJ,et al.Beneficial effect of brewers yeast extract on daily activity in a murine model of chronic fatigue syndrome［J］.Evid Based Complement Alternat Med，2006，3(1):109-115.
〔16〕 Karacabey K.Effect of regular exercise on health and disease［J］.Neuro Endocrinol Lett,2005,26(5):617-623.
〔17〕 Shephard RJ,Shek PN.Autoimmune disorders,physical activity,and training,with particular reference to rheumatoid arthritis［J］.Exerc Immunol Rev,1997，3:53-67.
〔18〕 Hutnick NA,Williams NI,Kraemer WJ,et al.Exercise and lymphocyte activation following chemotherapy for breast cancer［J］.Med Sci Sports Exerc,2005,37(11):1827-1835.
〔19〕 Timmons BW.Paediatric exercise immunology:health and clinical applications［J］.Exerc Immunol Rev,2005,11:108-144.
〔20〕 Boudreau J,Quadrilatero J,Hoffman-Goetz L,et al.Voluntary training in mice and submandibular lymphocyte response to acute exercise［J］.Med Sci Sports Exerc,2005,37(12):2038-2045.
〔21〕 Clapp LL,Richardson MT,Smith JF,et al.Acute effects of thirty minutes of light-intensity,intermittent exercise on patients with chronic fatigue syndrome［J］.Phys Ther,1999,79(8):749-756.
〔22〕 Coutts R,Weatherby R,Davie A,et al.The use of a symptom “self-report” inventory to evaluate the acceptability and efficacy of a walking program for patients suffering with chronic fatigue syndrome［J］.J Psychosom Res,2001,51(2):425-429.
〔23〕 Karen E Wallman,Alan R Morton,Carmel Goodman,et al.Exercise prescription for individuals with chronic fatigue syndrome［J］.MJA,2005,183(3):142-143.
〔24〕 Pauline Powell,Richard P.Patient education to encourage graded exercise in chronic fatigue syndrome 2-year follow-up of randomised controlled trial［J］.Br J Psychiatry,2004,184:142-146.
〔25〕 Powell P,Bentall RP,Nye FJ,et al.Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome［J］.BMJ,2001,322(7283):387-390.
〔26〕 Samoilovych VA,Hutarieva NV,Tondii LD,et al.Effect of physical factors on bioelectric properties of cell nuclei of buccal epithelium in students with chronic fatigue syndrome［J］.Lik Sprava,2005,(5-6):60-64.
〔27〕 Saidi G,Haines L.The management of children with chronic fatigue syndrome-like illness in primary care:a cross-sectional study［J］.Br J Gen Pract,2006,56(522):43-47.
〔28〕 Vilikus Z,Mareckova H,Janatkova I,et al.Risk factors for ischemic heart disease in patients with chronic fatigue syndrome［J］.Sb Lek,1998,99(1):53-61.
〔29〕 McCully KK,Malucelli E,Iotti S,et al.Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients［J］.Dyn Med,2006,5:1.
〔30〕 Nijs J,Van de Putte K,Louckx F,et al.Employment status in chronic fatigue syndrome.A cross-sectional study examining the value of exercise testing and self-reported measures for the assessment of employment status［J］.Clin Rehabil,2005,19(8):895-899.
〔31〕 Iasiukiavichene L,Vasiliauskas D.Chronic fatigue syndrome in cardiology n
