2.4 致癌性和诱变性 至今尚未见有关肉桂胶致癌性和诱变性研究的报道。已有的研究证实，其他胶如槐豆胶、瓜尔豆胶和tara胶，在相应的实验研究中喂食大鼠和小鼠是无致癌性和无诱变性的。其中化学结构上与肉桂胶相近的槐豆胶对F344/N大鼠或B6C3F1小鼠实验〔12〕无致癌性，并且无诱变性〔13〕。用含瓜尔豆胶浓度为25000μg/kg或50000μg/kg(大约每天1250mg/kgBW或2500mg/kgBW)的混合物饲养的F344/N大鼠或B6C3F1小鼠721d，无致癌性〔14〕。用含tara胶浓度为0、25000、50000μg/kg(每天0、1250、2500mg/kg bW)的饲料喂养F344/N大鼠2年，未发现与实验物质有关的致癌效果。〔15〕
3 结论
综上所述，肉桂胶急性口服毒性较低，在亚慢性、繁殖和生长毒性研究中未见明显的副作用。这些资料可为将肉桂胶考虑作为一般公认为安全物质(GRAS)在人和宠物食品中使用提供依据。
1 Klose R E, et al. Gums. In: T E Furia. handbook of food additives. Chemical Rubber Co, OH, 1968,335
2 Leung A Y, et al. Encyclopedia of common natural ingredients used in foods. drugs and Cosmetics. New York: John Wiley，Sons, Inc,1996,235
3 Denkler M. Derivatives of cassia. Freedom chemical diamalt Gm bH. US Pat/No.4743659, 1997,1,31
4 Di Salle U. Acute toxicity of Mucigel X-18-H in male rats. Nerlin: Schering aG, 1986
5 Schuh W. Systemic tolerance study in Beagle-dogs after daily oral (dietary) administration over a period of 90 days. Schering Study. No. TX88,404,Berling,1990
6 Virat M. Thirteen week toxicity study in the cat by the oral route.& nbsp;Institute francais de Toxicologie France Report. No. 411233,1989,11,21
7 Zuhlke U. Twenty-eight day oral (dietary administration and gavage) range-finding subchronic toxicity study in the rat. Hazelton Laboratories report. No. 702586,1990,11，20
8 Takahashi H, et al. Toxicity studies of partially hydrolyzed guar gum. Journal of the American College of Toxicology, 1994,13:273～278
9 Virat M. One-generation reproductive toxicology and subchronic toxicity study in cats. Hazelton France Report, No. 702586,1989,11,20
10 Mclntyre M D. Two generation oral (Dietary administration) reproduction toxicity study in the rat. Hazelton France. Report No 710791. Hazelton France. lesoncins, L Arbresle, Cedex. 26 1990,6
11 Muller W. Cral(gavage) teratogenicity study in the rat. Hazelton laboratories Report. No. 725-14/50 Hazelton Laboratories Deutschland Gm bH, kesselfeld Munster,1989,11,23
12 NTP Carcinogenesis bioassay of locust bean gum in F344/N rats and B6C3F1 mice. NTP-80-66,1981
13 Maxwell W A, et al. Study of the mutagenic effects of FDA-71-12(Locus bean gum). Stanford Research Institute. Stanford C A,1972
14 NTP Carcinogenesis bioassay of guar gum in F344/N rats and B6C3F1 mice. nTP-TR-229 NIH Publication No. 82-1785 US DHHS, Public Health Service, National institute of Health. Washington D C, 1982
15 Borzelleca J F, et al. Evaluation of the safety of tara gum as a food ingredient. A review of the literature. Journal of the American College of toxicology, 1993,12:81～89
