体内-体外相关性就是将药物剂型在体外的变化情况与其在体内的生物药剂学一药动学变化情况关联起来，它是体外溶出度和体内生物利用度参数的函数。也就是说研究某个药物制剂的体内-体外相关性的目的，在于建立一个可以说明生物利用度的体外质量标准，和用作制剂批量生产时的质控指标。即便当前由于体外溶出度测定与体内生物利用度评价存在一定的问题，但本作者相信随之科技的进步，体外溶出度测定试验在不久的将来在模拟体内行为方面会发挥更大的作用。
6、参考文献
[1]Ch P（2005）VolⅡ Appendix XC（中国药典2005年版.二部附录）［S］.2005：73-75.
[2]Ch P（2005）VolⅡ Appendix XIXB（中国药典2005年版.二部附录）[S］.2005：173-176.
[3]USP30-NF25 General Tests and Assays(美国药典30版)[S](711)DISSOLUTION.
[4]Br P(2000) VolⅡAppendix ⅦD（英国药典2000年版.二部附录）[S].2000:216-221.
[5]Questions & Answers on the Bioavailability and Bioequivalence Guideline. EMEA. 2006.
[6]Note for guidance on the Investigation on Bioavailability and Bioequivalence. EMEA. 2002.
[7]Note for chemical drugs’ guidance on the Investigation on Human Bioavailability andBioequivalence . CDE，2005.
[8]J-M. CARDTL, E. BEYSSAC, M.ALRIC. In Vitro–In Vivo Correlation: Importance of Dissolution in IVIVC. Dissolution Technologies, 2007: 15-19.
[9]LUO J,ZHU Z J.Biowaiver of generic drugs[J].Chinese Pharmaceutical Affairs(中国药事).2006 2(7) :430-433.
[10] LESLIE Z. BENET.Predicting Drug Absorption and Disposition by Application of BDDCS.2009.
[11]DING L,WANG J Q,ZHANG A L,et al.The comparations of dissolution research methods in China ,United States,British and Japan Pharmaceuticals[J]. JOURNAL OF JIANGXI UNIVERSITY OF TCM(江西中医学院学报).2008,20(1):1-3.
[12]CYNTHIA K.BROWN,HITESH P.CHOKSHI,BEVERLY NICKERSON,et al.AcceptableAnalytical Practices forDissolution Testing of Poorly Soluble Compounds. Pharmaceutical Technology ,Dec 2004 :56-65.
[13]HU W J,WAN X X.The in vivo-in vitro relationship research development of poorly soluble drugs for oral[J].J Bran Camp First Mil Med Univ(第一军医大学分校学报).2002,25(2):152-154.
[14]XIE M F，ZhANG Q M ，ChEN J,et al. Introduction on Foreign Drug Administration Evaluating the Internal Quality of Oral Solid Formulations by Drug Dissolution Curve. Chinese Pharmaceutical Affairs(中国药事).2008,22(3) :257-260.
[15]XIE M F.Improve dissolution rate evaluation methods and solid pharmaceuticals level[J]. Chinese Journal of Pharmaceuticals(中国医药工业杂志) 2005,36(7):477-451.
[16]YE D M,LAN SH.Dissolution determination of Allopurinol tablets between different factories. Guangxl Medical Journal(广西药学).2002,22(6):1301-1302.
[17]WANG P，ZHANG Q Y，PAN J.Dissolution rate and bioavailability comparison of Carbamazepine tablets from different factories.JIANGSU PHARMACEUTICAL AND CLINICAL RESEARCH(江苏药学与临床研究).2004,12(5):1-3.
[18]G. BRYAN CRIST.2009 Trends in Small-Volume DissolutionApparatus for Low-Dose Compounds.dissolution technology,2009:19-22.
[19]SHARON M.AVERELL Frost.Introduction to the Validation of a Dissolution Apparatus. Dissolution Technology,2004:19-21.
[20]LUCINDA (CINDY) BUHSE. Dissolution Apparatus Qualification.2006.
[21]ROCKVILLE.Guidance for Industry:Dissolution Testing of Immediate Release Solid Oral Dosage Forms.1997.
[22]VIVIAN GRAY, SAJI THOMAS.Dissolution Highlights of the AAPS Annual Meeting. Dissolution Technology,2007:35-36.
[23]LIMIN ZHANG, KHANH HA, BRENT KLEINTOP,et al.Differences in In Vitro Dissolution Rates Using Single-Point and Multi-Point Sampling. Dissolution Technology,2007 :27-31.
[24]RC LI,AHL CHOW,MS YIP,et al.Basic concepts of bioavailability.HKMJ.1995,1(1):63-68.
[25]IBEZIM, E. C., ATTAMA, et al.In vitro prediction of in vivo bioavailability and bioequivalence of brands of metronidazole tablets in Eastern Nigerian drug market. Sci. Res. Essays.2008,3(11):552-558.
[26]PADMANABH P.BHATT.Osmotic drug delivery systems for poorly soluble drugs.The Drug Delivery Companies Report Autumn/Winter 2004.
[27]C.KUMARESAN. In -Vitro In -Vivo Studies in Pharmaceutical Development. Latest Reviews.2008,6(2).
