结核分枝杆菌Mtb8.4DNA疫苗构建及免疫保护研究(4)
作者：佚名； 更新时间：2014-12-13
98，161:2356～2364.
［9］ Cole ST，Broseh R，Parkhill J，et al.Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence［J］.Na-ture，1998，393（6685）:537～544.
［10］Guleria L，Teitelbaum R，MeAdam RA，et al.Auxotrophic vaccines for tuberculosis［J］.Nat Med，1996，2:334～337.
［11］Chambers MA，Williams A，Gavier-Widen D，et al.Identification of a Mycobacterium boris BCG auxotrophic mutant that protects guinea pigs a-gainst M.boris and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin［J］.Infect Immun，2000，68:7094～7099.
［12］Murray P J，AIdovini A，Young RA.Manipulation and potentiation of an-timycobacterial immunity using recombinant Bacille Calmette-Guerin strains that secrete cytokines［J］.Proc Natl Acad Sci USA，1996，93:934～939.
［13］Marshall BG，Wangoo A，O'Gaora P，et al.Enhanced antimycobacterial response to recombinant MycobacteriumborisBCG expressing latency asso-ciated peptide［J］.Infect Immun，2001，69:6676～6682.
［14］Horwitz MA，Harth G，Dillon B J，et al.Recombinant bacillus Caimette-Guerin（BCG）vaccines expressing the Mycobacterium tuberculosis30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model［J］.Proc Natl dcad Sci USA，2000，97:13853～13858.
［15］Stewart GR，Snewin VA，Walzl G，et al.Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection［J］.Nat Med，2001，7:732～737.
［16］ Smith DA，Parish T，Stoker NG，et al.Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine can-didates［J］.Infect Immun，2001，69:1142～1150.
［17］吴乃虎.基因工程原理［M］.第2版.北京:科学出版社，2001，474～481.
［9］ Cole ST，Broseh R，Parkhill J，et al.Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence［J］.Na-ture，1998，393（6685）:537～544.
［10］Guleria L，Teitelbaum R，MeAdam RA，et al.Auxotrophic vaccines for tuberculosis［J］.Nat Med，1996，2:334～337.
［11］Chambers MA，Williams A，Gavier-Widen D，et al.Identification of a Mycobacterium boris BCG auxotrophic mutant that protects guinea pigs a-gainst M.boris and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin［J］.Infect Immun，2000，68:7094～7099.
［12］Murray P J，AIdovini A，Young RA.Manipulation and potentiation of an-timycobacterial immunity using recombinant Bacille Calmette-Guerin strains that secrete cytokines［J］.Proc Natl Acad Sci USA，1996，93:934～939.
［13］Marshall BG，Wangoo A，O'Gaora P，et al.Enhanced antimycobacterial response to recombinant MycobacteriumborisBCG expressing latency asso-ciated peptide［J］.Infect Immun，2001，69:6676～6682.
［14］Horwitz MA，Harth G，Dillon B J，et al.Recombinant bacillus Caimette-Guerin（BCG）vaccines expressing the Mycobacterium tuberculosis30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model［J］.Proc Natl dcad Sci USA，2000，97:13853～13858.
［15］Stewart GR，Snewin VA，Walzl G，et al.Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection［J］.Nat Med，2001，7:732～737.
［16］ Smith DA，Parish T，Stoker NG，et al.Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine can-didates［J］.Infect Immun，2001，69:1142～1150.
［17］吴乃虎.基因工程原理［M］.第2版.北京:科学出版社，2001，474～481.
