【Abstract】：Objective: To evaluate the Impact of serum prolactin conncentration on the day of human chorionic gonadotropin( hCG) administration on clinical outcome of in vitro  fertilization  and  embryo  transfer  (IVF-ET). Methods: 202cycles of IVF-ET/ICSI-ET performed in Reproductive Medical Center of the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences from October 2005 to March 2008 were analyzed retrospectively. Results: Patients were divided into four groups according to serum prolactin concentration (≤30ng/ml(A组),＞30～≤60ng/ml(B组),＞60～≤90ng/ml(C组),＞90ng/ml(D组)) on the day of hCG administration. Implantation rate was 22.20%, 19.75% and 11.83% respectively and pregnancy rate (PR) was 25.00%、42.70%、27.30% and 5.88% respectively in this 4 groups. In prolactin ＞90ng/ml group, implantation rate and PR were low, comparing with other groups. The difference was statiscally significant. Conclusion: During controlled ovarian stimulation,serum prolactin conncentration was much higner than basal level 。 Implantation rate and clinical pregnancy rate significantly decreased when serum prolactin concentration  dramatically increased(＞90ng/ml). To improve the clinical pregnancy rate of IVF-ET，tight monitoring and appropriate intervention are needed for patients with abnormal prolactin level during controlled ovarian stimulation.

　　【Key Words】 transitory hyperprolactinemia ;in vitro ertilization and embryo transfer；human chorionic gonadotropin( hCG);clinical pregnancy

　　【论文关键词】暂时性高催乳素;体外受精与胚胎移植；人绒毛膜促性腺激素；临床妊娠  

　　［论文摘要］  目的 探讨在体外受精与胚胎移植（IVF-ET）中，注射人绒毛膜促性腺激素（HCG）日血清催乳素(PRL)浓度对妊娠的影响。方法回顾性分析2005年10月～2008年3月202个体外受精与胚胎移植周期的资料。结果 在控制性卵巢刺激（COS）中，按注射HCG日血清催乳素浓度不同分4组，依次为≤30ng/ml(A组),＞30～≤60ng/ml(B组),＞60～≤90ng/ml(C组),＞90ng/ml(D组)。体外受精与胚胎移植的种植率分别为11.76%、 19.71%、 12.72%、2.22%；临床妊娠率分别为25.00%、42.70%、27.30%、5.88%。PRL> >90ng/ml组的种植率及临床妊娠率比其它组低，经χ2 检验，P值分别为0.011和0.009，有统计学意义。结论  控制性卵巢刺激后血清催乳素浓度较基础水平明显升高,HCG注射日血清催乳素明显升高（> 90ng/ml）时，体外受精与胚胎移植的种植率及临床妊娠率明显下降。建议对COS过程中催乳素水平异常的病人给予严密的监测和适当的干预，有助于提高临床妊娠率。

　　在体外受精-胚胎移植的控制性卵巢刺激（controlled ovary stimulation，COS）过程中，血清催乳素浓度的变化对IVF-ET结局的影响，国内外相关报道很少，且结果不一，本研究回顾性分析了我中心2005年10月～2008年3月202个IVF-ET周期的资料，报告如下。

　　资料与方法

　　一、研究对象

　　研究对象为2005年10月至2008年3月在中山大学附属第一医院生殖医学中心接受体外受精-胚胎移植(IVF-ET)/卵胞浆内单精子注射-胚胎移植(ICSI-ET)的不孕病人,共有197个病人共202个治疗周期列入研究范围。排除标准:有催乳素分泌异常或垂体腺瘤病史的病人。其不孕原因包括男方因素56例、女性输卵管因素103例、盆腔粘连15例、子宫内膜异位症17例及其它11例（排卵障碍、多次人工受精失败及不明原因等）。