63、傅枝莲，王日太，宗可诚.羟基喜树碱与喃氟啶治疗老年人结直肠癌临床观察.滨州医学院学报，2003，23:12-122.

64、张闯.羟基喜树碱联合化疗治疗晚期消化系统恶性肿瘤临床观察.四川治疗防治，2002，15:11- 12.

65、Cunningham D，Pyrh.Onen S， James RD，et al.Randomised trial of irinotecan plus           supportive care versus supportive care alone after fluorouracil failure for patients    with metastatic colorectal cancer.Lancet，1998，352:1413-1418.

66、RougierP，Cutsem EV，Bajettae， et al.Randomized trial of irinotecan versus          fluorouracil by continuous infusion after fluorouracil failure in patients with    metastatic colorectal cancer Lancet，1998，352:1407-1412.

67、SaltZ LB，Cox JV，Blanke C，et al. Irinotecan plus fluorouracil and leucovorin for    metastatic colorectal cancer.Nengl J Med，2000，343:905-914.

68、王肇炎，王尔兵.结直肠癌的靶向治疗.肿瘤研究与临床杂志2006，18:73-75.

69、Tabemero J，Rojo F，Jimenez E，et al.A phase I PK and sereial tumor and skin pharmacodynamic(PD)study of weekly(qlw)，every2- week(q2w) or every 3-week(q3w) l- hour(h) infusion EMD 72000， a humanized monoclonal   antiepidermal growth factor receptor(EGFR)antibody， in patients(pt) with  [advanced tumors abstract]    770.Proc Am Soc Clin Oncol，2003，22:192.

70、Hurwitz H， Holden SN，Sarkar S， et al.Clinical benefit from bevacizumab(BV) in responding(R) and non- responding(NR) patients(pts) with metastatic colorectal     cancer(mCRC).Proc Am Soc Clin Oncol， 2005(Abstr3514).

71、 Saltz LB，Cox JV，Blanke C，et al.Irinotecan plus fluorouracil and leucovorin for       metastatic colorevctal cancer.Irinotecan study group.N Engl J Med，2000，343:905- 914.

72、Douillard JY，Cunningham D,Routh AD， et al.Irinotecan combined  with fluorouracil compared with fluorouracil alone as first -line treatment for metastatic colorectal cancer.a multicentre randomized trial.Lancet,2000,355:1041-1047

73、 Kohne CH， Van Cutsem E， Wils JA， et al.    Irinotecan improve the activity of      the AIO regimen in metastatic colorectal cancer. Results of EORTC GI group study     40986.Proc Am Soc Clin Oncol，2003，22:abstr 1018.

74、 de Gramont A,Boni C，Navarro 1M et al.Oxaliplatin/ 5.Fu/LV in the adjuvant            treatment of stage II and III colon cancer.Efficancy result with a median follow·up of 4years.4lth ASCO Annal Meeting Proceeding.2005，2465:3501.

75、Tournigand C，Andre T，Aehille E， et al.FOLFIRI followed by FOLFOX6 or      the reverse sequence in advanced colorectal cancer. A randomized GERCOR  study.J Clin Oncol，2004，22:229-237.

76、Arkenau H，Sehmoll H，Kubicka S，et al.Infusional 5-fluorouracil/folinic acid     plus oxaliplatin(FUFOX) versus capecitabine plus oxaliplatin(CAPOX) as first         line treatment of metastatic colorectal caneer(MCRC):Results of the safety and     efficacy analysis.Proc Am Soc Clin Oncol， 2005:abstr3507.

77、 E.C.Popa，W.Luo，H.Hochster，B，et al.A phase II study of ORZEL(UFT+LV) in eldly (75    years old)patients with colorectal cancer:results of ECOG 1299.Proe Am Soc Clin Oncol， 2005:abstr3608.

78、张守亮，上茂龙.结直肠癌淋巴靶向化疗的研究进展.国外医学肿瘤学分册，2003，30:381-384.

79、李啸峰，迟宝荣，马琳.结直肠癌多药耐药研究进展.吉林大学学报(医学)饭)，2003，29:700一702